CHANGES OF LIPIDOM IN COLORECTAL CANCER
M.V. Kruchinina1, A.A. Gromov1, Ia.I. Prudnikova1, V.N. Kruchinin2, M.V. Shashkov3, V.N. Sidelnikov3, A.S. Sokolova4, N.F. Salakhutdinov4
1Institute of Internal and Preventive Medicine - Branch of Federal Research Institute of Cytology and Genetics of SB RAS, 630089, Novosibirsk, Boris Bogatkov str., 175/1
2Rzhanov Institute of Semiconductor Physics SB RAS, 630090, Novosibirsk, Akademician Lavrentyev av., 13
3Boreskov Institute of Catalysis SB RAS, 630090, Novosibirsk, Akademician Lavrentyev av., 5
4Vorozhtsov Institute of organic chemistry SB RAS, 630090, Novosibirsk, Akademician Lavrentyev av., 9
Keywords: колоректальный рак, липидомика, дисрегуляция, патогенез, colorectal cancer, lipidome, dysregulation, pathogenesis
Abstract
Colorectal cancer is the second cause of death among all deaths, caused by malignant tumors in the world. Understanding its pathophysiology is important for developing effective strategies for treating this disease. Lipidome, a combination of total lipids, lipid-linked enzymes, receptors and signaling pathways play an important role in numerous cellular processes such as metabolism, energy storage, proliferation and apoptosis. The disturbances in the regulation of lipid metabolism and their functions contribute to the development and progression of colorectal cancer and can be used to assess the prognosis. For a whole range of directions, the dysregulation of lipid metabolism in colorectal cancer is similar to that in the development of cardiovascular pathology. Strategies aimed at lipidome have been used in clinical studies and have shown promising results. This review presents recent advances in the study of impaired lipid metabolism in colorectal cancer, the mechanisms by which lipid metabolites regulate carcinogenesis and tumor progression, and potential therapeutic targets for future clinical trials.
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