STATINS PROTECTIVE ROLE IN PATIENTS WITH CHRONIC TOTAL OCCLUSIONS OF CORONARY ARTERIES IN INTRACORONARY INTERVENTIONS
A.S. Ragozina1, I.V. Petrenko1, A.I. Gor’kov1, I.A. Urvantseva1, K.Yu. Nikolaev2
1State-financed organization Khanty-Mansi Autonomous Region - Ugra District Cardiodispensary В«Centre of diagnosis and Cardiovascular Surgery», 628403, Surgut, Lenin av., 69/1
2Institute of Internal and Preventive Medicine - Branch of Federal Research Institute of Cytology and Genetics of SB RAS, 630089, Novosibirsk, Boris Bogatkov str., 175/1
Keywords: хронические окклюзии коронарных артерий, аторвастатин, реканализация, чрескожное коронарное вмешательство, шкала SYNTAX, chronic total occlusion of coronary arteries, atorvastatin, recanalization, percutaneous coronary intervention, SYNTAX Score
Abstract
The study objective is evaluate atherosclerosis burden on atorvastatin protective effect in patients with chronic total occlusion recanalization. Methods. 38 patients underwent recanalization of chronic total occlusions. All patients received a loading dose of atorvastatin 80 mg before surgery. Further patients were divided into high and low risk group according to SYNTAX score. In both groups, troponin I, CF fraction of creatine phosphokinase, functional parameters of the myocardium were measured 1 day prior to surgery, 24 hours and 1 month after the surgery. Results. In the high risk group there was discovered more significant troponin I rising compared with low risk group. In the low risk group troponin I level was significantly lower. CF fraction of creatine phosphokinase in both groups was similar. There were no statistically significant changes in echocardiography parameters. Conclusion. Atorvastatin loading dose has a protective effect and prevents periprocedural myocardial ischemia. At the same time this effect appears only in patients with low atherosclerosis burden - SYNTAX score less than 19.5. At the same time it doesn’t influence on central hemodynamics in short-term period.
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