ASSOCIATION OF COMBINATIONS OF ALLELIC VARIANTS OF CYP2C19 AND VEGFR2 GENES WITH CORONARY ATHEROSCLEROSIS IN ACUTE CORONARY SYNDROME IN THE NORTH AND IN SIBERIA
K.Yu. Nikolaev1,2, I.A. Urvantseva3, K.Yu. Batueva3, K.A. Apartsin4,5, A.V. Gorokhova4,5, V.I. Ganyukov6, N.A. Kochergin6, E.M. Zelenskaya7, G.I. Lifshits2,7
1Institute of Internal and Preventive Medicine - Branch of Federal Research Institute of Cytology and Genetics of SB RAS, 630089, Novosibirsk, Boris Bogatkov str., 175/1
2Novosibirsk State National Research University, 630090, Novosibirsk, Pirogov str., 2
3Surgut State University, 628400, Surgut, Lenin str., 69/1
4Irkutsk Scientific Center of SB RAS, 664033, Irkutsk, Lermontov str., 134
5Irkutsk orders В«The Honour Sign» Regional Clinical Hospital, 664033, Irkutsk, Lermontov str., 134
6Institute for Complex Issues of Cardiovascular Diseases, 650002, Kemerovo, Sosnovy Boulevard, 6
7Institute of Chemical Biology and Fundamental Medicine, 630090, Novosibirsk, Academician Lavrentyev av., 8
Keywords: острый коронарный синдром, атеросклероз коронарных артерий, аллельные варианты генов VEGFR2*C/*C и CYP2C19*17/*17, acute coronary syndrome, arteriosclerosis of coronary arteries, allelic variants of VEGFR2*C/*C and CYP2C19*17/*17 genes
Abstract
Purpose: to study associations of homozygous allelic variants of VEGFR2*C/*C and CYP2C19*17/*17 genes with atherosclerotic lesion of coronary arteries in patients with acute coronary syndrome (ACS) in the North (Surgut) and in large cities of the Siberian Federal District of Russia (Irkutsk and Kemerovo). 257 consecutive patients with ACS upon admission to the cardiological hospitals of Surgut, Irkutsk and Kemerovo has been included in the study. All examined patients underwent coronarography and determination of allelic variants of VEGFR2*C/*C and CYP2C19*17 /*17 genes. In patients from Surgut has been determened the direct associations of the combination of allelic variants of VEGFR2*C/*C + CYP2C19*17/*17 with indicators of severe coronary atherosclerosis (lesion of the left coronary artery trunk (LCA), LCA stenosis more than 50 %, proximal or medial lesion of the three major arteries more than 70 % (PLA) and the presence of PLA or stenosis of the LCA trunk more than 50 %). Such associations were not found in patients from Kemerovo and Irkutsk. The multivariate analysis determined the direct effect of combination of allelic variants of the VEGFR2*C/*C and CYP2C19*17/*17 genes on the presence of PTA or stenosis of the LCA trunk more than 50 % in patients with ACS from Surgut regardless of males gender, ages and smoking (Exp B) = 21.065, 95 % CI (2.003; 221.524), p = 0.011). Thus, the combination of allelic variants of VEGFR2*C/*C and CYP2C19*17/*17 genes directly affects the presence of severe coronary atherosclerosis in patients with ACS from Surgut.
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