CHARACTERISTICS OF Dyslipidemia and the DURATION of rheumatoid arthritis IN WOMEN
Yu.N. Starodubova1,2, I.V. Osipova1
1Altai State Medical University of Minzdrav of Russia, 656038, Barnaul, Lenin av., 40
2City Hospital N4, 656050, Barnaul, Yurin str., 166 A
Keywords: rheumatoid arthritis, female, markers of inflammation, dyslipidemia, peripheral atherosclerosis
Abstract
Purposeis: to study the characteristics of dyslipidemia and its types depending on the duration of rheumatoid arthritis, to determine the most significant combination of risk factors for the development of atherosclerosis in women with rheumatoid arthritis (RA). Material and methods: 223 women with RA were examined; the mean age was 55.3 ± 6.8 years. The patients were divided into 2 groups, depending on the duration of RA:group 1 included the patients with early RA lasting less than a year ( n = 87) and group 2 - more than 1 year ( n = 136). The patients from the group 2 were older than the women from the group 1 (55.7 ± 2.9 and 49.6 ± 1.4 years, respectively) ( p < 0.01). The analysis of risk factors for cardiovascular disease (CVD), blood lipid profile and markers of chronic inflammation, RA activity (VAS, DAS28), subclinical atherosclerosis markers was made. Total cardiovascular risk assessment in patients with RA was performed with mSCORE scale. Results. Dyslipidemia in women with RA is associated with markers of inflammatory activity (C-reactive protein (CRP), erythrocyte sedimentation rate (ESR), rheumatoid factor (RF) and it is characterized by the increased LDL, triglycerides (TG), atherogenic index (AI) and decreased HDL. The increased level of total blood cholesterol was found to have been always associated with the abnormal content of other components of the lipid profile. Atherogenic dyslipidemia in early RA (group 1) occurred in 1.2 times more frequently than in patients having RA more than a year (72 and 62 % respectively), which is associated with the immune-inflammatory activity ( p < 0,05). Having been evaluated by mSCORE scale the risks for CVD in the groups were very high and high in more than 50 % of cases ( p < 0.05). Conclusion Dyslipidemia was common in groups. The significant predictors for atherosclerosis in women with RA can be supposed to be early menopause, pregnancy pathology, sleep disorders, depression, hypertension, increased total cholesterol level, LDL, AI, TG decreased HDL, high activity according to DAS 28, increased erythrocyte sedimentation rate, prednisolone taking.
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