NEW METHOD OF PERSONIFIED EVALUATION OF RISK OF CARDIOVASCULAR DISEASES BY THE COEFFICIENT OF ATHEROGENICITY
L.D. Latyntseva1, K.V. Makarenkova1, O.V. Tsygankova2, O.V. Timoshchenko1
1Institute of Internal and Preventive Medicine - Branch of Federal Research Institute of Cytology and Genetics of SB RAS, 630089, Novosibirsk, Boris Bogatkov, 175/1
2Novosibirsk State Medical University of Minzdrav of Russia, 630089, Novosibirsk, Boris Bogatkov, 175/1
Keywords: coefficient of atherogenicity, cardiovascular risk, dyslipidemia, SCORE scale
Abstract
The aim of the work is to develop a new atherogenic coefficient as a personalized method for assessing cardiovascular risk in patients with dyslipidemia. Materials and methods. The subject of the study was a sample of men and women ( n = 100 people) with lipid metabolism disorders aged 50-70 years (mean age 58.7 ± 3.2 years) without documented cardiovascular pathology, diabetes mellitus, hereditary dyslipidemia. As a result of the research, a new CA was created and tested, including additional non-lipid risk factors, which was calculated using the formula: risk SCOREЧ(non-HDL-C/HDL-C). Results and discussion. Positive correlation of coefficient values with conventional factors of cardiovascular risk: age, levels of TC and LDL cholesterol, systolic blood pressure, lipid coefficient of atherogenicity, and estimated risk for SCORE, the latter being the strongest. Negative, reliable correlation of the new CA was found with the female sex of patients. Important for clinical practice is the fact that it does not require invasive intervention and significant time and material costs for an additional examination.
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