MOLECULAR-GENETICAL MARKERS OF LIPID ABNORMALITIES AND SUDDEN CARDIAC DEATH
A.A. Ivanova
Institute of Internal and Preventive Medicine, 630089, Novosibirsk, Boris Bogatkov str., 175/1
Keywords: sudden cardiac death, single nucleotide polymorphism, APOE, LIPC, SREBF2, USF1, CETP, USF1, LDLR
Abstract
Sudden cardiac death is one of main problem of modern medicine. Sudden cardiac death is about 50 % of all cardiac deaths. The main part of people who died of sudden cardiac death didn’t have any cardiac illnesses. In the world molecular genetic markers of sudden cardiac death are studied to create an effective system of diagnostic of predisposition and prophylactic of sudden deaths, especially to people without cardiac diseases. Lipid abnormalities are one of risk factor of sudden cardiac death. Single nucleotide polymorphisms of CETP, APOE, SREBF2, SCAP, LIPC, USF1, LDLR genes were studied as molecular genetic markers of sudden cardiac death.
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