CRYSTAL STRUCTURE OF PSEUDOKOPSININE AND ITS SALTS
Sh. M. Adizov1, B. Tashkhodzhaev1, R. Zh. Kunafiev2, M. M. Mirzaeva1, P. Kh. Yuldashev1
1Yunusov Institute of the Chemistry of Plant Substances, Academy of Sciences of the Republic of Uzbekistan, Tashkent, Republic of Uzbekistan
2Sadykov Institute of Bioorganic Chemistry, Academy of Sciences of the Republic of Uzbekistan, Tashkent, Republic of Uzbekistan
Keywords: индолиновые алкалоиды, псевдокопсинин, галоидные соли, РСА, indoline alkaloids, pseudokopsinine, haloid salts, single crystal XRD
Abstract
The X-ray diffraction study of an indoline alkaloid of pseudokopsinine extracted from the plant Vinca erecta and its mono- and double salts is performed. The experimentally determined positions of Н atoms suggest the sp 3 hybridization of the indoline nitrogen atom in the base and salts. The pseudokopsinine base and double salt have an intramolecular Н bond between the NH group proton and the ether oxygen atom of the methoxycarbonyl group, which is absent in the monosalt and the related indolines. The intermolecular Н bonds and/or the packing efficiency cause a conformational change in F and Е heterocycles in the indoline hetero framework of pseudokopsinine salts in comparison with that observed in the base.
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