EFFECTS OF LUDARTIN AND GROSSHEMIN ON EXPERIMENTAL HYPERLIPIDEMIA INDUCED BY TRITON WR 1339
A.V. Ratkin1, O.A. Kaidash1, V.V. Ivanov1, V.S. Chuchalin1, S.M. Adekenov2, A.I. Vengerovskiy1
1Siberian State Medical University, 634050, Tomsk, Moskovsky trakt, 2
ratkin@ssmu.ru
2JSC В«International scientific-industrial holding “Phytochemistry”», Karaganda, Kazakhstan, M. Gazaliyev str., 4
phyto_pio@mail.ru
Keywords: ludartin, grosshemin, triton WR 1339, gemfibrozil, sesquiterpene Оі-lactones, experimental hyperlipidemia, lipid-lowering effect
Abstract
The hypolipidemic action of sesquiterpene γ-lactones ludartin and grosshemin was studied in vivo experiments on the model of acute hyperlipidemia induced by Triton WR 1339. Hyperlipemia model induced by Triton WR 1339, characterized by a sharp increase in the content in the serum of triacylglycerides and total cholesterol, mainly due to the increase of cholesterol in proatherogenic fractions of lipoproteins (low density). Hypolipidemic action of ludartin and grosshemin on the background of triton WR 1339 induced hyperlipemia, and drug comparison of phenofibrate, evident decrease in the content of triacylglycerides and pro-atherogenic cholesterol in low density lipoproteins in the blood serum, as well as reducing the amount of triacylglycerides and cholesterol in the liver of rats.
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