APOPTOSIS AND APOPTOTIC EXTRACELLULAR VESICULAR PARTICLES IN ATHEROGENESIS
Yu.Sh. Shwartz, M.I. Chasovskikh, S.V. Cheresiz, M.V. Kruchinina
FSBSI В«Institute of Internal and Preventive Medicine», 630089, Novosibirsk, Boris Bogatkov str., 175/1
Keywords: атеросклероз, апоптоз, эффероцитоз, внеклеточные везикулярные частицы, atherosclerosis, apoptosis, efferocytosis, extracellular vesicular particles
Abstract
The review summarizes current notions on the role of apoptosis and apoptotic cell-derived extracellular vesicles in atherogenesis. The mechanisms of efferocytosis impairment and its significance in atherosclerotic vulnerable plaque formation are discussed. The data on the pro- and anti-inflammatory effects of apoptotic extracellular vesicular particles are presented.
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