LIPID PROFILE, BLOOD PRESSURE, QUALITY OF LIFE AND CLINICAL FEATURES OF GALLSTONE DISEASE COMBINED WITH ARTERIAL HYPERTENSION
M.S. Lebedeva1,2, I.N. Grigorieva1,3, V.N. Maksimov1
1FSBSI В«Institute of Internal and Preventive Medicine», 630089, Novosibirsk, Boris Bogatkov str., 175/1
2В«Russian Railways» Open Joint Stock Company Railway Clinical Hospital on the Station Novosibirsk-Glavnyi, 630003, Novosibirsk, Vladimirovskiy spusk, 2a
3Novosibirsk State University, 630090, Novosibirsk, Pirogov str., 2
Keywords: коморбидность, желчно-каменная болезнь, артериальная гипертензия, comorbidity, gallstone disease, arterial hypertension
Abstract
Aim. To study some features of metabolism (total cholesterol, HDL, LDL, triglycerides), blood pressure (BP), the clinical course of gallstone disease (GSD) and the quality of life (QoL) in women with GSD in combination with arterial hypertension (AH). Materials and methods. During open clinical study were examined 152 patients aged 30-60 years: 55 women with GSD and AH (group 1), 50 women with GSD without AH (group 2) and 47 women with AH without GSD (group 3). Patients of three groups were matched for age, BMI, frequency of comorbid cardiovascular diseases and diabetes mellitus type 2 ( p > 0.05). QoL was assessed by questionnaire MOS SF-36. Results. Patients of group 1 noticed pain in the right upper quadrant and dyspeptic symptoms more frequently, as compared to group 2 ( p < 0.05). Patients of group 1 showed higher values of the average sistolic blood pressure (148.4±2.6 vs. 140.1±2.8 mmHg) and diastolic blood pressure (92.0±1.3 vs. 84.9±1.5 mmHg), an increased frequency of hyper-TChol (89.1 vs. 72.3 %, p < 0.05) and hyper-LDL >3.0 mmol/l (90.9 vs. 74.5 %, p < 0.05) compared to group 3. Reducing the QoL in group 1 compared to group 3 was recorded at 4 scales and compared to group 2 - at 5 scales of 8 of questionnaire MOS SF-36 ( p < 0.05). Conclusion. Gastroenterological symptoms, lipids level and blood pressure, as well as QoL, were worse in comorbided patients with GSD and AH, compared to patients with isolated pathologies.
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