METABOLIC SYNDROME AND COGNITIVE FUNCTION IN THE MIDDLE AND OLDER POPULATION OF NOVOSIBIRSK
S.V. Shishkin1, S.V. Mustafina1, S.K. Malyutina1, M. Bobak2, G.I. Simonova1, L.V. Shcherbakova1, Yu.I. Ragino1, M.I. Voevoda1
a:2:{s:4:"TYPE";s:4:"HTML";s:4:"TEXT";s:218:"1FSBSI «Institute of Internal and Preventive Medicine», 630089, Novosibirsk, Boris Bogatkov str., 175/1
2Department of Epidemiology and Public Health, University College London, London, UK";}
Keywords: метаболический синдром, когнитивная функция, компоненты метаболического синдрома, metabolic syndrome, cognitive function, the components of the metabolic syndrome
Abstract
Objective: To investigate the association of metabolic syndrome (MS) and its individual components with indicators of cognitive function (CF) in a population sample of older people in Western Siberia. Material and methods . The current analysis, conducted in the frame of project supported by RSF, used the data from the international project HAPIEE which recruited a random population sample of 9.360 men and women aged 45-69 years old resident in Novosibirsk. Immediate and delayed word recall and verbal fluency tests were used to assess cognitive functions in a random subsample ( n = 4765). Metabolic syndrome was based on measurements of blood pressure, anthropometry, blood lipids and blood glucose levels. Results . After adjustment for age, sex and education, the mean immediate word recall and verbal fluence were significantly lower in subjects with MS than in persons without MS ( p < 0.05); the difference in delayed recall was not significant ( p > 0.05). Cognitive functions were significantly inversely associated with presence of all individual components of MS. Conclusion . This large study in general population of middle aged and older persons in a large industrial center of Western Siberia, we found a significant decline in cognitive functions associated with MS and its components.
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