METABOLIC SYNDROME AND COGNITIVE FUNCTION IN THE MIDDLE AND OLDER POPULATION OF NOVOSIBIRSK
S.V. Shishkin1, S.V. Mustafina1, S.K. Malyutina1, M. Bobak2, G.I. Simonova1, L.V. Shcherbakova1, Yu.I. Ragino1, M.I. Voevoda1
1FSBSI В«Institute of Internal and Preventive Medicine», 630089, Novosibirsk, Boris Bogatkov str., 175/1
2Department of Epidemiology and Public Health, University College London, London, UK
Keywords: метаболический синдром, когнитивная функция, компоненты метаболического синдрома, metabolic syndrome, cognitive function, the components of the metabolic syndrome
Abstract
Objective: To investigate the association of metabolic syndrome (MS) and its individual components with indicators of cognitive function (CF) in a population sample of older people in Western Siberia. Material and methods . The current analysis, conducted in the frame of project supported by RSF, used the data from the international project HAPIEE which recruited a random population sample of 9.360 men and women aged 45-69 years old resident in Novosibirsk. Immediate and delayed word recall and verbal fluency tests were used to assess cognitive functions in a random subsample ( n = 4765). Metabolic syndrome was based on measurements of blood pressure, anthropometry, blood lipids and blood glucose levels. Results . After adjustment for age, sex and education, the mean immediate word recall and verbal fluence were significantly lower in subjects with MS than in persons without MS ( p < 0.05); the difference in delayed recall was not significant ( p > 0.05). Cognitive functions were significantly inversely associated with presence of all individual components of MS. Conclusion . This large study in general population of middle aged and older persons in a large industrial center of Western Siberia, we found a significant decline in cognitive functions associated with MS and its components.
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