THE ROLE OF POLYMORPHISMS WITHIN GENES ENCODING TOLL-LIKE RECEPTORS IN CORONARY ATHEROSCLEROSIS
A.V. Ponasenko1, M.V. Khutornaya1, A.G. Kutikhin1, I.I. Zhidkova1, A.S. Golovkin2, O.L. Barbarash1
1Research Institute for Complex Issues of Cardiovascular Diseases, 650002, Kemerovo, Sosnovy blvd., 6
2Federal North-West Medical Research Centre, 197341, St. Petersburg, Akkuratov str., 2
Keywords: ишемическая болезнь сердца, атеросклероз, врожденный иммунитет, TLR, генные полиморфизмы, coronary artery disease, atherosclerosis, innate immunity, Toll-like receptors, gene polymorphisms
Abstract
Study aim: To investigate an association of the Toll-like receptor (TLR) gene polymorphisms with the risk of coronary artery disease (CAD). Materials and Methods: We recruited 702 consecutive Russian patients with CAD and 300 healthy blood donors who were residents of Western Siberia (Kemerovo Region). We investigated eight polymorphisms within four genes: TLR1 (rs5743551, rs5743611), TLR2 (rs3804099, rs5743708), TLR4 (rs4986790, rs4986791), and TLR6 (rs3775073, rs5743810). Sample genotyping was performed in 96-well format using the TaqMan SNP genotyping assay. Results: C/C genotype of rs5743551 polymorphism and C/G genotype of rs5743611 polymorphism within TLR1 gene along with T/C genotype of rs3775073 polymorphism and A/G genotype of rs5743810 polymorphism within TLR6 gene were associated with a high risk of coronary artery disease (OR = 0.41 (95 % CI = 0.20-0.84), OR = 1.56, 95 % CI = 1.04-2.34, OR = 1.68, 95 % CI = 1.03-2.73, and OR = 1.55 (95 % CI = 1.12-2.14, р < 0,05, respectively) independently of age and gender. Conclusions: certain Toll-like receptor gene polymorphisms are associated with the risk of CAD.
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