THE SUPPRESSOR CELLS - THE BASIS OF IMMUNOPATHOGENESIS OF ATHEROSCLEROSIS
V.A. Kozlov
Scientific Research Institute of Fundamental and Clinical Immunology, 630099, Novosibirsk, Yadrintsevskaya str., 14
Keywords: immunopathogenesis of atherosclerosis, immunological tolerance, immunocompetence cells with suppressor activity
Abstract
Atherosclerosis is a vascular disease, in the formation of which is attended immunocompetent cells (macrophages, dendritic cells, lymphocytes), endothelial and smooth muscle cell elements in interaction with the lipoprotein enriched with cholesterol. Thus, circulating CD4+ T lymphocytes are differentiated mainly in Th1 cells that respond to specific antigens, such as oxidized LDL and heat shock proteins (HSP60/65) induces the processes of endothelial damage and smooth muscle cells). The question that will or will not develop atherosclerosis depends on balanced participation in the process regulatory cells with suppressor activity, in particular CD4+CD25+Foxp3+ Treg. Numerous data suggest about the reduction of Treg in patients with atherosclerosis and reducing their suppressor activity. All therapeutic effects of stimulating the activity of Treg positively influence the course of experimental atherosclerosis.
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