THE mRNA EXPRESSION PROFILE OF GENES OF INNATE IMMUNE RECEPTORS IN THE PATHOGENESIS OF ATHEROSCLEROSIS
V.A. Ipatova, A.V. Ponasenko
Research Institute for Complex Issues of Cardiovascular Disease, 650002, Kemerovo, Sosnovy Blvd., 6
Keywords: mRNA, expression, genes, atherosclerosis, innate immunity
Abstract
The article covers the relevance of studying mRNA expression profile of genes of innate immune receptors, in particular genes of TLRs. The ability of TLRs to express at the surface of various cells, even at those that do not belong to the innate and adaptive immune responses, has been defined. mRNA structure has been reviewed. The meta-analysis of studies investigating the role of TLRs genes in the development and progression of cardiovascular diseases, including atherosclerosis, both in clinical practice and in animal experiments, has been performed. The results of the meta-analysis are presented in the conclusion section.
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