ASSOCIATION OF INHERITED VARIATION WITHIN THE GENES ENCODING Toll-LIKE RECEPTORS WITH DISORDERS OF CARBOHYDRATE METABOLISM AMONG PATIENTS WITH CORONARY ARTERY DISEASE
A.S. Golovkin, A.V. Ponasenko, A.G. Kutikhin, I.I. Zhidkova, M.V. Khutornaya, R.R. Salakhov, O.L. Barbarash
Research Institute for Complex Issues of Cardiovascular Diseases, 650002, Kemerovo, Pine Avenue, 6
Keywords: ischemic heart disease, type 2 diabetes mellitus, atherosclerosis, Toll-like receptors, gene polymorphisms
Abstract
Aim of the study. To determine the impact of polymorphisms within the genes encoding Toll-like receptors on the development of carbohydrate metabolism disorders (CMDs) amongst patients with coronary artery disease (CAD). Materials and Methods. We recruited 292 patients with CAD and investigated 8 polymorphisms within 4 genes, namely TLR1 (rs5743551 and rs5743611), TLR2 (rs3804099 and rs5743708), TLR4 (rs4986790 and rs4986791), and TLR6 (rs3775073 and rs5743810). Results. Carriers of G allele of rs5743611 polymorphism within TLR1 gene had an increased risk of CMDs. Moreover, the risk of CMDs was 3-fold higher in carriers of G/G genotype of rs5743611 polymorphism between 50 and 70 years of age. However, carriers of Т allele of rs4986791 (Thr399Ile) polymorphism and G allele of rs4986790 (Asp299Gly) polymorphism within TLR4 gene had decreased risk of CMDs. In addition, A/A genotype of rs5743810 polymorphism within TLR6 gene was associated with reduced risk of CMDs in males. Conclusion. There are certain associations of polymorphisms within genes encoding Toll-like receptors and development of CMDs amongst patients with CAD.
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