THE CONTRIBUTION OF TOLL-LIKE RECEPTOR GENES IN THE ETIOPATHOGENESIS OF CORONARY ARTERY DISEASE
V.A. Ipatova, A.V. Ponasenko, M.V. Khutornaya, A.V. Tsepokina, A.S. Golovkin
Research Institute for Complex Issues of Cardiovascular Diseases of SB RAMS, 650002, Kemerovo, Sosnovy Blvd., 6
Keywords: atherosclerosis, genes, polymorphisms, allelic variants, Toll-like receptors
Abstract
The article presents a review of current meta-analyses on innate immune receptor gene polymorphisms, such as Toll-like receptors, and their potential role in the pathogenesis of coronary atherosclerotic lesions. TLR signaling pathways, as well as available allelic variations of genes encoding them, and the relationship between TLR polymorphic variants with different pathological conditions have been described. The article reveals significant associations of individual TLR gene alleles with the development and progression of atherosclerosis in different populations. However, the research in this area is rather limited and requires further study.
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