Genetics of longevity: telomere length of leukocytes as a marker of aging and a risk factor for age-related diseases in humans
V.N. Maksimov1, E.N. Voropaeva1, M. Bobak2, S.K. Malyitina1, M.I. Voevoda1
1Research Institute of Internal and Preventive Medicine of SB RAMS, 630089, Novosibirsk, Boris Bogatkov str., 175/1
2University College London, Inined Kingdom, London, 1-19 Torrington Place
Keywords: genetics of longevity, telomere length, a marker of aging, risk factors, polymerase-chain reaction, age-dependent diseases
Abstract
The manuscript is devoted to review in the area of genetics of longevity (current state of knowledge), in particular, the use of leukocyte telomere length measurement as a marker of aging and as an indicator of the risk for age-related diseases in humans. The paper also gives an overview of laboratory methods to assess telomere length. In the frame of pilot study of the project on biomarkers of «biological age» in Russian population (grant RCSF) the method for analysis of telomeres length by real-time PCR on the base of technique by Cawthon (2002) was tested. The results of testing provided required accuracy, reproducibility of method’s was of 95,5 %, the tried and tested technique will be used for analysis in present project.
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