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The journal "Ateroskleroz"

2014 year, number 3

THE STUDY OF ASSOCIATION BETWEEN LIPID FRACTIONS LEVELS AND IMMEDIATE AND DELAYED REPRODUCTION OF VERBAL INFORMATION

A.V. Sukhanov, D.V. Denisova, Yu.I. Ragino
Research Institute of Internal and Preventive Medicine of SB RAMS, 630089, Novosibirsk, Boris Bogatkov str., 175/1
Keywords: test Luria, cognitive function, serum lipids

Abstract

Background: The literature data about the association between disorders of immediate and delayed reproduction of the verbal information with lipid levels in young and middle age at the present time remains controversial. Objective: To examine the association of different levels of lipid fractions with direct and delayed recall of words in the A.R. Luria test at the each five-year period in both sexes aged 25-45. Methods: The study involved 536 people aged 25 to 45 years - Novosibirsk residents of both sexes. The concentration of serum lipid levels were measured by enzymatic method. Immediate and delayed reproduction of words was assessed using the technique of memorizing 10 words, proposed A.R. Luria. Analysis of the material was carried out using the methods of descriptive statistics, correlation analysis and multiple linear regression in the statistical package «R» for Windows. Results: The levels of total cholesterol showed a weak positive correlation with the number of words with delayed reproduction in Luria test that found its confirmation when performing regression analysis. At the same time, the triglyceride levels negatively correlated with the average number of correctly named words with direct playback, which is also confirmed by multiple linear regression. Conclusion: Association of lipid profile and the assessment of cognitive functions fails to recognize at a young age. Analysis of the associations in the future may be of great interest for the detailed development of the theory of memory.