THE STRUCTURAL CHARACTERISTICS OF THE WALL OF CAROTID ARTERIES IN OLDER WOMEN AND THEIR PROSPECTIVE DETERMINANTS IN THE POPULATION
S.K. Malyutina1,2, Yu.Yu. Palekhina2, A.N. Ryabikov1,2, S.G. Shakhmatov1,2, M. Bobak3
1Research Institute of Internal and Preventive Medicine of SB RAMS, 630089, Novosibirsk, Boris Bogatkov str., 175/1
2Novosibirsk State Medical University of Minzdrav of Russia, 630091, Novosibirsk, Krasny av., 52
3University College London, United Kingdom, London, 1-19 Torrington Place
Keywords: intima-media, atherosclerosis, carotid arteries, women, population, risk factors, cardiovascular disease
Abstract
Purpose: To study the age gradient and prospective determinants of the structural characteristics of the arterial wall in the Novosibirsk population of older women (in the cross-sectional and prospective analysis). Methods and data source: Random population sample (338 women, 52-79 years) was examined with ultrasound of the carotid arteries (CA) and repeated epidemiological evaluation of CVD and risk factors. The materials of baseline survey performed at age of 45-69 years were used. The average follow-up period was of 8.5 years. We analyzed age gradient of carotid intima-media thickness (CIMT) and carotid atherosclerotic plaques (СP) and their association with risk factors in cross-sectional and prospective design. Results: The mean maximum CIMT was ( M ± SE ) 0.79 ± ± 0.01mm (75 ‰ = 0.89 mm), the frequency of CP - 54.2 %. CIMT increased by 0.06-0.07 mm by age decade, frequency CP increased from 31 % to 73 % in women aged 52-79 years old. In cross-sectional analysis CIMT was positively associated with age, SBP, history of diabetes with treatment. Prospective predictors CIMT were: age SBP and menopause, measured at age 45-69 years old. In cross-sectional analysis CP was positively associated with age, SBP, smoking, presence of CVD and negatively associated with alcohol intake. Prospective predictors of CP were age, SBP, LDL cholesterol and smoking, measured at age 45-69 years old. Conclusion: In female Siberian population aged 52-79 the reference value of CIMT was 0.89 mm (corresponding to established criteria 0.90 mm). Age gradient of CIMT increase and CP frequency were calculated. The determinants of CIMT were age, systolic blood pressure, diabetes with treatment history (in older age) and the menopause (in middle age). The presence of CP were determined by age, systolic blood pressure, LDL cholesterol, and smoking (in middle and older age), and it was negative associated with alcohol intake and positively - with history of CVD (in older age). The study results can be used to improve prevention of atherosclerosis in women.
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