SOME COMMON CANDIDATE GENES IN ARTERIAL HYPERTENSION AND GALLSTLONE DISEASE PATHOGENESIS
M.S. LEBEDEVA1,2, I.N. GRIGORIEVA1, N.P. TATARNIKOVA1, V.N. MAKSIMOV1
1Research Institute of Internal and Preventive Medicine of SB RAMS, 630089 , Novosibirsk, Boris Bogatkov str., 175/1
2В«Russian Railways» Open Joint Stock Company Railway Clinical Hospital on the Station Novosibirsk-Glavnyi, 630003, Novosibirsk, Vladimirovskiy spusk, 2a
Keywords: gene polymorphism, APOE, ADRB1, ACE, gallstone disease, arterial hypertension, полиморфизм генов, APOE, ADRB1, АПФ, желчно-каменная болезнь, артериальная гипертензия
Abstract
Gallstone disease (GSD) and arterial hypertension (AH) have many common risk factors - age, overweight, dyslipidemia, low physical activity, diabetes mellitus, in addition, the presence of AH is considered by many authors as a risk factor for GSD. Numerous trials are devoted to the study of the contribution of gene polymorphisms in the development of AH, but researches about common candidate genes for AH and GSD are rare. In several studies, including a meta-analysis, the association of GSD and APOE4 allele genotype is depicted. Our clinical study in women with GSD in combination with AH shows the greatest frequency of allele APOE4 (21.2) compared with women with GSD without AH (8.0) or with women with isolated AH (10.6, p < 0.05). Also in this study, we found no significant differences in the frequency of genotypes A/A, A/G and G/G polymorphism A145G ADRB1 gene in women with AH in combination with GSD and women with isolated AH. Earlier in epidemiological study we did not found any association of GSD with I/D polymorphism of angiotensin converting enzyme gene. Thus, further research is needed to find a common candidate genes involved in the regulation of blood pressure and in the development of GSD in each population that will help identify patients at highest risk of complications of GSD and AH.
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