About the Mechanism of the Analgesic Activity of Highly Efficient Analgesics of the New Structural Type: in vitro Experiments
E. A. MOROZOVA1, T. A. ZAPARA2, A. S. RATUSHNYAK2, S. O. VECHKAPOVA2, T. G. TOLSTIKOVA1 and E. E. SHULTS1
1Vorozhtsov Novosibirsk Institute of Organic Chemistry, Siberian Branch of the Russian Academy of Sciences,
Pr. Akademika Lavrentyeva 9, Novosibirsk 630090 (Russia)
E-mail: morozova@nioch.nsc.ru
2Design and Technological Institute of Computer Engineering, Siberian Branch of the Russian Academy of Sciences,
Ul. Rzhanova 6, Novosibirsk 630090 (Russia)
Keywords: pyrrolidinomorphinanes, membrane potential, isolated neurons, opioid receptors
Pages: 285–289
Abstract
The effect of pyrrolidinomorphinane derivatives possessing an analgesic activity on the membrane potential of isolated neurons of a mollusc treated with selective antagonists of opioid receptors was studied. The results confirm the opioid mechanism of the action of these compounds shown earlier in experiments in vivo on mice and indicate the nonselectivity of the interaction of the agent T-11 with all types of opioid receptors, as well the preference of the interaction of the agent Sh-42 with κ-receptors.
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