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Chemistry for Sustainable Development

2014 year, number 3

Effect of the Nanoaerosol Form of Medicinal Preparations on Their Basic Activity

S. V. AN'KOV1, T. G. TOLSTIKOVA1, M. V. KHVOSTOV1, A. A. ONISCHUK2, A. M. BAKLANOV2 and V. V. BOLDYREV3
1Vorozhtsov Novosibirsk Institute of Organic Chemistry, Siberian Branch, Russian Academy of Sciences,
Pr. Akademika Lavrentyeva 9, Novosibirsk 630090 (Russia)
E-mail: tg_tolstikova@mail.ru
2Institute of Chemical Kinetics and Combustion, Siberian Branch, Russian Academy of Sciences
Ul. Institutskaya 3, Novosibirsk 630090 (Russia)
E-mail: onischuk@kinetics.nsc.ru
3Novosibirsk State University, Research and Education Centre for Molecular Design and Ecologically Safe Technologies,
Ul. Pirogova 2, Novosibirsk 630090 (Russia)
E-mail: boldyrev@solid.nsc.ru
Keywords: nanoaerosols, diclofenac, ibuprofen, caffeine, barbital
Pages: 219–223

Abstract

The pharmacological effect of the nano aerosol form of diclofenac, ibuprofen, caffeine and barbital in vivo was studied. It was established that such a delivery way allowed significantly decreasing the dose not only preserving the base activity, but also elevating it.