SOI Nanowire Transistor for Detection of D-NFATc1 Molecules
Yu. D. Ivanov1, T. O. Pleshakova1, A. F. Kozlov1, K. A. Mal’sagova1, N. V. Krokhin1, A. L. Kaisheva1, I. D. Shumov1, V. P. Popov2, O. V. Naumova2, B. I. Fomin2, D. A. Nasimov2, A. L. Aseev2, A. I. Archakov1
1Orekhovich Institute of Biomedical Chemistry, Russian Academy of Medical Sciences, ul. Pogodinskaya 10, Moscow, 119121 Russia
2Rzhanov Institute of Semiconductor Physics, Siberian Branch, Russian Academy of Sciences, pr. Akademika Lavrent’eva 13, Novosibirsk, 630090 Russia
Keywords: aptamer, biosensor, D-NFATc1, silicon-on-insulator, nanowires
Abstract
Nanowire (NW) detection is one of the fast and highly sensitive methods. An NW biosensor based on silicon-on-insulator (SOI) structures are used in the reported study for real-time label-free biospecific detection of the NFATc1 (D-NFATc1) cancer marker. For this purpose, the SOI NWs are functionalized with NFATc1 aptamers used as macromolecular probes. It is demonstrated that such a biosensor can ensure a detection limits up to 10−15 M, which is comparable with the sensitivity ensured by an NW biosensor with immobilized antibodies used as macromolecular probes. The results of this study demonstrate that such approaches to the development of sensor elements for highly sensitive diagnostics of diseases are really promising.
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