Mechanochemical Modification of the Properties of Antihelminthic Preparations
S. S. KHALIKOV1, M. S. KHALIKOV1, E. S. METELEVA2, S. A. GUSKOV2, V. I. EVSEENKO2, A. V. DUSHKIN2, V. S. BURANBAEV3, R. G. FAZLAEV4, V. Z. GALIMOVA4 and A. M. GALIULLINA4
1 Research Technological Institute of Herbicides and Plant Growth Regulators with Experimental Production, Academy of Sciences of the Republic of Bashkortostan,
Ul. Ulyanovykh 65, Ufa 450029 (Russia)
salavatkhalikov@mail.ru
2 Institute of Solid State Chemistry and Mechanochemistry, Siberian Branch of the Russian Academy of Sciences,
Ul. Kutateladze 18, Novosibirsk 6300128 (Russia)
3 Republic of Bashkortostan, Department of Veterinary,
Ul. Pushkina 106, Ufa 450001 (Russia)
4 Bashkir State Agricultural University,
Ul. 50 Let Oktyabrya 34, Ufa 450001 (Russia)
Keywords: antihelminthic preparations, carbendacim, albendazole, polymers, polysaccharides, grinding, mechanical activation, supramolecular complexes water solubility, particle size, nanotechnology, mechanochemical synthesis, echinococcosis
Pages: 653–657
Abstract
The processes of joint mechanical activation of some benzimidazole antihelminthic preparations with water-soluble polymers in the mills of shock-attrition type were studied. The conditions of synthesis of supramolecular complexes with different components ratios and energy strain of activator mills were discussed. The products of mechanochemical synthesis were characterized on the basis of water solubility and particle size. The products obtained possess higher water solubility and smaller particle size than the initial benzimidazole compounds; the products are of interest as potential antihelminthic preparations with increased efficiency.
UDC 544.52+544.526.2+547.32
|
