Synthesis and Biological Activity of the Derivatives of Alkaloid Cytisine
I. V. KULAKOVВ В andВ В O. A. NURKENOV
Institute of Organic Synthesis and Coal Chemistry, Republic of Kazakhstan, Ul. Alikhanova 1, Karaganda 100008 (Kazakhstan)
E-mail: kulakov_iv@mail.ru
Keywords: alkaloid cytisine, cytisine derivatives, 1Н NMR spectroscopy, X-ray structural analysis, biological activity
Pages: 237–250
Abstract
Results of the investigations carried out by the authors during the past five years in the area of chemical transformation of cytisine alkaloid are presented. A number of new polyfunctional derivatives of cytisine alkaloid containing pharmacone groups including heterocyclic fragments were obtained. The composition and structure of the synthesized compounds were confirmed by means of the data of mass spectrometry, 1Н NMR spectroscopy and X-ray structural analysis. Some features of the spatial structure of cytisine were established. The data obtained in the investigation of the biological activity of the synthesized derivatives are presented.
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