Synthesis and Modification of ОІ--Xylofuranosylnucleosides
Akhat Mustafin, Alfiya Gimadieva, Ildus Abdrakhmanov, Genrich Tolstikov
Keywords: ОІ-xylofuranosyl nucleosides, silyl method, -xylose, thymine, uracil, azidothymidine, ellipticine, 6, 7-difluoroquinolocarboxylic acid
Pages: 735-738
Abstract
Original schemes of the synthesis of known anti-HIV preparations azidothymidine and
2',3'-didesoxy-2',3'-didehydrothymidine (D4T) are reported. The possibility to use the silyl method in the synthesis of glycosides of biologically active nitrogen-containing heterocycles is demonstrated.
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