Home – Home – Jornals – Chemistry for Sustainable Development 2008 number 6

Outlooks for the use of triterpenoids of lupane series in medical practice are discussed. Among native compounds, especially important one is betulic acid, a highly efficient anti-cancer agent and inhibitor of ЕСНО6 enterovirus. The most promising semi-synthetic derivatives of lupane series are amides, ureides, dipeptides and acylates of betulic, betulonic and 3-oximinonetulonic acids possessing high anti-HIV activity, pronounced anti-tumour and organ-protecting action. It is shown that the production of biologically active additives with betuline extract is actively developing.