Home – Home – Jornals – Chemistry for Sustainable Development 2008 number 6

Selective transformations of triterpene glycoside (glycyrrhizic acid), which is the main biologically active component of the roots of (Glycyrrhiza glabra L.) and (Gl. uralensis Fisher) at the carbohydrate chain and/or aglycon were carried out. New groups of biologically active compounds valuable for medicine were obtained (amides, glycopeptides, pyrazoles, conjugates with aminosaccharides, triterpene glycosides), possessing high anti-inflammatory, antiulcerogenic, immunopotentiating and antiviral activity. It was established that chemical modification of glycyrrhizic acid by adding amino acids, dipeptides and amino saccharides into the carbohydrate part of its molecule opens the outlooks for the synthesis of new stimulants of the humoral immune response, antiHIV-1-, antoSARS CoV- and antiEBV-agents.