Synthesis of Polyfunctional Chlorines Based on Methylpheophorbyde а and Its Analogs
Dmitriy Belykh, Alexander Kuchin
Keywords: methylpheophorbide а , chlorophyll, chlorine
Pages: 617-629
Abstract
Application of methylpheophorbyde а as an initial compound for the synthesis of potential anticancer agents is considered. The possibility to carry out a number of reactions participated by the main reaction centres of methylpheophorbyde а (exocycle, vinyl group, propionate substituent) for preparative purposes is shown. The use of the reactions of the main centres provides the possibility to obtain porphyrin compounds of diverse structures. All the synthesized compounds have a chlorine pharmacophore in the molecule, which ensures their activity as photosensitising agents for photodynamic therapy of oncological and other diseases.
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