Investigation of Biological Safety of Nanosubstances and Nanomaterials
T. G. Tolstikova1, E. A. Morozova1, M. V. Khvostov1, P. P. Laktionov2, E. S. Morozkin2, Z. R. Ismagilov3, O. Y. Podyacheva3, S. V. Sysolyatin4, A. B. Vorozhtsov4, R. K. Tukhtaev5, C. N. Barnakov6
1 Vorozhtsov Novosibirsk Institute of Organic Chemistry, Siberian Branch of the Russian Academy of Sciences
2 Institute of Chemical Biology and Fundamental Medicine, Siberian Branch of the Russian Academy of Sciences
3 Boreskov Institute of Catalysis, Siberian Branch of the Russian Academy of Sciences
4 Institute for Problems of Chemical and Energetic Technologies, Siberian Branch of the Russian Academy of Sciences
5 Institute of Solid State Chemistry and Mechanochemistry, Siberian Branch of the Russian Academy of Sciences
6 Institute of Coal and Coal Chemistry, Siberian Branch of the Russian Academy of Sciences
Keywords: metal nanopowder, toxicity, in vivo, in vitro
Pages: 445-452
Abstract
Results of the toxicological investigation in vivo and in vitro of nanosubstances and nanomaterials obtained at the Institutes of the Siberian Branch of the RAS are presented. It was established that, on the basis of acute toxicity value, the nanopowders of the oxides of aluminium, zinc, titanium, and carbon materials may be related to the class 3 (moderately toxic) or the class 4 (low toxicity), while nanopowders of copper correspond to the class 2 of toxicity. It is demonstrated through the in vitro investigation involving titanium nanopowder as an example that metal nanopowders can be highly toxic for various primary (healthy) cells but cause no death of cancer cells.
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