Complexing of Pharmacons with Glycyrrhizic Acid as a Route to the Development of the Preparations with Enhanced Efficiency
A. V. Dushkin1, E. S. Meteleva1, T. G. Tolstikova2, M. V. Khvostov2, M. P. Dolgikh2, G. A. Tolstikov2
1 Institute of Solid State Chemistry and Mechanochemistry, Siberian Branch of the Russian Academy of Sciences
2 Vorozhtsov Novosibirsk Institute of Organic Chemistry, Siberian Branch of the Russian Academy of Sciences
dushkin@solid.nsc.ru
Keywords: complexing, glycyrrhizic acid, pharmaceutical dosage forms, enhancement of drug efficiency
Pages: 437-444
Abstract
Gel chromatographic investigation of the aqueous solutions of glycyrrhizic acid was carried out. A mechanochemical route to obtaining its compositions with poorly soluble pharmaceutical substances was developed, the characteristics of their aqueous solutions were studied, and their pharmacological characteristics were examined.
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