Hydroxyketones of para-Menthane Series as Promising Analgesic
A. V. Pavlova, T. G. Tolstikova, E. A. Morozova, O. V. Ardashov, I. V. Il'ina, K. P. Volcho, N. F. Salakhutdinov
Vorozhtsov Novosibirsk Institute of Organic Chemistry, Siberian Branch of the Russian Academy of Sciences
volcho@nioch.nsc.ru
Keywords: monoterpenoids of para-menthane series, analgesic activity, mice
Pages: 415-417
Abstract
Data obtained in the investigation of the analgesic activity of monoterpenoid of the para-menthane series - 2-hydroxy-3-methyl-6-(1-methylethenyl)cyclohex-3-enone are presented. It is discovered that two its spatial isomers (2R,6S and 2S,6R) in the dose of 2.5 mg/kg exhibit high analgesic activity and to a substantial extent quench the development of pain syndrome caused by the introduction of acetic acid. With the hot plate model, a substantial effect of the absolute configuration of the terpenoid on the direction of action is demonstrated.
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