Effect of Betulonic Acid and Its Derivatives on the Morphology of Kidneys in the Animals with Transplanted Lewis Lung Carcinoma at the Background of Polychemotherapy and without It
N. A. Zhukova1, I. V. Sorokina1, T. G. Tolstikova1, M. P. Dolgikh1, D. E. Semenov2
1 Vorozhtsov Novosibirsk Institute of Organic Chemistry, Siberian Branch of the Russian Academy of Sciences
2 Scientific Research Institute of Regional Pathology and Pathomorphology, Siberian Branch of the Russian Academy of Medical Sciences
sorokina@nioch.nsc.ru
Keywords: polychemotherapy, Lewis lung carcinoma, nephroprotective effect, betulonic acid, [3-oxo-20(29)-lupen-28-oyl]-3-aminopropionic acid and their methyl esters
Pages: 403-408
Abstract
Effect of betulonic and [3-oxo-20(29)-lupen-28-oyl]-3-aminopropionic acids and their methyl esters on the morphology of kidneys of the C57BL/6 mice with transplanted Lewis pulmonary adenocarcinoma at the background of cytostatic polychemotherapy (cyclophosphane, adriamycin, vincrystine, prednisolone) and without it was investigated. It was established by means of morphometry that the introduction of betulonic and [3-oxo-20(29)-lupen-28-oyl]-3-aminopropionic acids and their methyl esters against the background of polychemotherapy and without it has a positive effect on the course of tubulointerstitial nephropathy as it reduces the degree of necrotic and dystrophic changes of epithelial cells of proximal tubules as well as reduces the edema of interstitial tissue.
|
