Synthesis and Biological Activity of Novel Acetylene Betulonic Acid Derivatives
A. I. Govdi1, I. V. Sorokina2, T. G. Tolstikova2, S. F. Vasilevsky1, G. A. Tolstikov2
1 Institute of Chemical Kinetics and Combustion, Siberian Branch of the Russian Academy of Sciences
2 Vorozhtsov Novosibirsk Institute of Organic Chemistry, Siberian Branch of the Russian Academy of Sciences
sorokina@nioch.nsc.ru, vasilev@kinetics.nsc.ru
Keywords: triterpenoids, betulonic acid, aryl acetylenes, hepatoprotective activity, anti-inflammatory activity
Pages: 397-402
Abstract
Acetylene derivatives of betulonic acid amide were synthesized. Their hepatoprotective and anti-inflammatory activity was investigated. In the series of betulonic acid derivatives, two compounds with a substantial hepatoprotective and anti-inflammatory effect were revealed.
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