Mechanochemical Solubilization of Piroxicam with the Use of Microcrystalline Cellulose that Was Produced by Means of Catalytic Delignification of Sawdust of Aspen Wood
S. A. Myz1, T. P. Shakhtshneider2, V. V. Boldyrev3, S. A. Kuznetsova4, B. N. Kuznetsov5, V. G. Danilov6, O. V. Yatsenkova7, A. S. Medvedeva8
1 Novosibirsk State University Ul. Pirogova 2, Novosibirsk 630090 (engsia), apenina@solid.nsc.ru
2 Institute of Solid State Chemistry and Mechanochemistry Novosibirsk State University Ul. Pirogova 2, Novosibirsk 630090 (engsia)
3 Institute of Solid State Chemistry and Mechanochemistry Novosibirsk State University Ul. Pirogova 2, Novosibirsk 630090 (engsia)
4 Institute of Chemistry and Chemical Technology
5 Institute of Chemistry and Chemical Technology
6 Institute of Chemistry and Chemical Technology
7 Institute of Chemistry and Chemical Technology
8 Favorsky Institute of Chemistry
Abstract
An environmentally sound method to produce microcrystalline cellulose (MCC) has been developed. Conditions have been adjusted that make it possible to produce top-quality MCC with a good yield. The produced MCC is highly competitive with commercial samples in its performance. By means of combined mechanical activation of piroxicam and MCC that was obtained following a new technology, compositions have been prepared that offer higher than usual speed of dissolving of a medicinal substance. It has been demonstrated that "graft complexes" are formed between MCC and piroxicam as a result of interaction of the ingredients to form hydrogen bonds.
|
