Obtaining the Ethers and Esters of Rickardine C as Potential Inhibitors of Nitric Oxide Synthase
Y. S. Kosenkova, M. P. Polovinka, N. I. Komarova, D. V. Korchagina, N. F. Salakhutdinov
Keywords: Primula macrocalyx Bge., rickardine С, ethers and esters of rickardine C, inhibitors of NO synthase
Pages: 495-506
Abstract
Rickardine С (1), natural 18-membered macrocyclic bisbibenzyl and inhibitor of NO synthase, was extracted by us from Primula macrocalyx Bge. A series of modifications of compound 1 by interaction with various halogenides and anhydrides of acids in the presence of bases, resulting in the formation of ethers and esters of rickardine C, was obtained (4-15). The structure of the latter compounds was established using spectral methods and mass spectrometry.
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