Electronic structure and specroscopic properties of norfloxacin, enoxacin, and nalidixic acid
Keywords: fluoroquinolones, antibacterial activity, X-ray photoelectron spectroscopy, electronic structure, UV absorption spectra, luminescence, quantum-chemical calculation, Mulliken charges
Pages: 456-460
Abstract
The X-ray photoelectron spectra (XPS) of the core electrons of the carbon, oxygen, nitrogen, and fluorine atoms of antibiotics from the class of quinolones (nalidixic acid, norfloxacin, and enoxacin), having different antibacterial activities, were measured and interpreted. The integrated intensities of the π-π* and n-π* transition bands in the absorption spectra of the compounds were analyzed. The maxima of the luminescence spectral bands are given along with the lifetimes of the excited states and quantum yields of the protolytic forms of the compounds in aqueous media. The XPS data were compared with the Mulliken charges on heteroatoms obtained by quantum-chemical calculations.
|
