Outlooks for the Application of Polymers to the Development of New Combined Medical Preparations of Isonicotinic Acid Hydrazide
L. P. OVCHARENKO, E. V. KOMPANTSEVA and V. A. SHAKOVA
Pyatigorsk State Pharmaceutical Academy, Pr. Kalinina 11, Pyatigorsk 357532 (Russia)
E-mail: nio@helios.ru
Pages: 249-254
Abstract
Processes involved in the interaction of some high-molecular compounds with the hydrazide of isonicotinic acid (isoniazid) and (+)-1,1'-ethylenediamine-N,N'-bis-(1-hydroxymethylpropane)dihydrochloride (ethambutol hydrochloride) in aqueous solutions are investigated. The deserving character of viscosimetry to be applied for the investigation of the formation of complexes of polymers with hydrophilic substances is validated for isoniazid and ethambutol hydrochloride. The data obtained are of special interest for the development of the chemistry of medications and for the elaboration of new highly efficient medical products.
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