Comparative Estimation of Cu, Zn, Pb and Cd Contents in Healthy People and in Patients with Blood Oncology Diseases
N. F. ZAKHARCHUK1, G. S. SOLDATOVA2, T. V. NOVIKOVA2 and N. S. BORISOVA1
1Nikolaev Institute of Inorganic Chemistry, Siberian Branch of the Russian Academy of Sciences, Pr. Akademika Lavrentyeva 3, Novosibirsk 630090 (Russia)
E-mail: nzak@che.nsk.su
2Central Clinical Hospital of the Russian Academy of Sciences, Ul. Pirogova 25, Novosibirsk 630090 (Russia)
E-mail: sgs@nm.ru
Pages: 231-240
Abstract
Inversion voltammetry method was used to test 52 healthy people and 28 patients with Hodgkin's lymphoma (HL) (all Novosibirsk citizens) for the content of microelements such as Cu, Zn, Pb and Cd. In the blood and urine of healthy people zinc, lead and cadmium content was found to fit conventional norm, while Cu content in blood and its fractions was at the lowermost norm level. Copper content in the whole blood of the HL sick people insignificantly differed from that typical for healthy people. However, one of the main homeostasis parameters, namely copper and zinc balance in blood and urine, was disturbed. In particular, there was essential zinc deficit in blood, while in urine zinc was in excess. Moreover, all HL sick patients had insufficient cadmium excretion and blood lead deficit in comparison to the control group. Organic selenium containing, food supplement "Nutricon-Selenium" was clinically tested. Its administration brought zinc excretion to norm, but noticeably increased imbalance between copper and zinc in blood.
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