On the Mechanism of Mechanochemical Synthesis of Phthalylsulphathiazole
MICHAEL A. MIKHAILENKO1,2, TATIANA P. SHAKHTSHNEIDER2,3 AND VLADIMIR V. BOLDYREV1,2,3
1Novosibirsk State University, Ul. Pirogova 2, Novosibirsk 630090 (Russia), E-mail: boldyrev@nsu.ru 2Research and Education Center "Molecular Design and Ecologically Safe Technologies"
at the Novosibirsk State University, Ul. Pirogova 2, Novosibirsk 630090 (Russia)
3Institute of Solid State Chemistry and Mechanochemistry,
Siberian Branch of the Russian Academy of Sciences, Ul. Kutateladze 18, Novosibirsk 630128 (Russia), E-mail: mikhailenko@solid.nsc.ru
Pages: 367-371
Abstract
This work deals with mechanochemical synthesis of phthalylsulphathiazole involving fluid phases. Model optical microscopy experiments with crystal samples have revealed that sulphathiazole can interact with phthalic anhydride without direct contact of these substances at temperatures of about 100oC. Scanning calorimetry measurements showed that the synthesis temperature is lowered during mechanical activation of reagents. The reagents do not undergo fusion under the conditions of mechanical activation. Transport of phthalic anhydride through the gas phase was assumed to be the most likely mechanism of synthesis in a mechanochemical reactor.
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