Издательство СО РАН

Издательство СО РАН

Адрес Издательства СО РАН: Россия, 630090, а/я 187
Новосибирск, Морской пр., 2

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Яндекс.Метрика

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Журнал структурной химии

2017 год, номер 8

CRYSTAL STRUCTURES OF 1-ARYL-4-(BIARYLMETHYLENE)PIPERAZINE AND PIPERIDINE, STRUCTURALLY RELATED TO ADOPRAZINE

N. Ullah1, M. Altaf2, M. Mansha1,2
1Chemistry Department, King Fahd University of Petroleum and Minerals, Dhahran, Saudi Arabia
nullah@kfupm.edu.sa
2Centre of Research Excellence in Nanotechnology, King Fahd University of Petroleum and Minerals, Dhahran, Saudi Arabia
Ключевые слова: 1-aryl-4-(biarylmethylene)piperazine, 1-aryl-4-(biarylmethylene)-piperidine, 5-HT receptor, D receptor, schizophrenia
Страницы: 1747-1751

Аннотация

8-(1-([1,1¢-biphenyl]-4-ylmethyl)piperidin-4-yl)-3,4-dihydroquinolin-2(1 H )-one (1) and 8-(4-([1,1¢-biphenyl]-4-ylmethyl)piperazin-1-yl)quinolin-2(1 H )-one (2) are prepared in the crystalline state and studied by X-ray diffraction. The crystal packing drawing of compound (1) indicates that individual molecules are linked by pairs of N-H⋯O hydrogen bonds forming A-A and B-B inversion dimers, with (8) ring motifs. These dimers are stabilized by N-H⋯O hydrogen bonds and linked via C-H⋯O short contact interactions forming a two-dimensional network. In the case of compound (2), there are two independent molecules A and B linked by pairs of N-H⋯O hydrogen bonds forming A-A and B-B inversion dimers, with (8) ring motifs. These dimers are stabilized by N-H⋯O hydrogen bonds and linked via C-H⋯O short contact interactions forming a two-dimensional network.
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