Издательство СО РАН

Издательство СО РАН

Адрес Издательства СО РАН: Россия, 630090, а/я 187
Новосибирск, Морской пр., 2

soran2.gif

Baner_Nauka_Sibiri.jpg


Яндекс.Метрика

Поиск по журналу

Журнал структурной химии

2016 год, номер 5

2-METHYLPYRIDINIUM 5-(2,4-DINITROPHENYL)-6-OXO-2-THIOXO-1,2,3,6-TETRAHYDROPYRIMIDIN-4-OLATE: SYNTHESIS, CRYSTAL STRUCTURE, AND BIOLOGICAL EVALUATION

G. Mangaiyarkarasi, G. Sridevi, P. Poornima Devi, D. Kalaivani
Seethalakshmi Ramaswami College, Tamil Nadu, India
kalaivbalaj@yahoo.co.in
Ключевые слова: carbon-bonded anionic sigma complex, 2-thiobarbituric acid, 1-chloro-2,4-dinitrobenzene, single crystal X-ray diffraction studies, anticonvulsant activity, maximal electroshock method
Страницы: 1035-1040

Аннотация

The titled complex is synthesized from the ethanolic solutions of 1-chloro-2,4-dinitrobenzene, 2-thiobarbituric acid, and 2-methylpyridine and characterized by spectral and elemental analyses. The single crystal X-ray diffraction results for the complex are compatible with the spectral observations. The titled complex exhibits anticonvulsant activity and reduces all phases of convulsion even at a low dosage. Acute toxicity studies of the complex are performed to understand the safer dose concentration for clinical trials.

DOI: 10.15372/JSC20160519
Добавить в корзину
Товар добавлен в корзину