STRUCTURES AND ANTIMICROBIAL ACTIVITY OF FLUORO- AND HYDROXY-SUBSTITUTED THIOCARBOXYHYDRAZONES
Z.-X. Liu
School of Chemistry and Chemical Engineering, Linyi University, Linyi Shandong, P. R. China
zengxin_liu@163.com
Ключевые слова: synthesis, hiocarboxyhydrazones, antimicrobial activity, crystal structure, hydrogen bonding, synthesis, hiocarboxyhydrazones, antimicrobial activity, crystal structure, hydrogen bonding
Страницы: 1476-1480
Подраздел: КРАТКИЕ СООБЩЕНИЯ
Аннотация
A series of fluoro- and hydroxy-substituted thiocarboxyhydrazones, 2-(3-fluorobenzylidene)-N-methylhydrazinecarbothioamide (1), 2-(2,3-difluorobenzylidene)-N-methylhydrazinecarbothioamide (2), and 2-(2-hydroxybenzylidene)-N-methylhydrazinecarbothioamide (3), are synthesized and characterized by elemental analysis, IR and UV-vis spectra, and single crystal X-ray diffraction. Structures of the three compounds are similar, but with a slight modification due to fluoro substituting groups. The crystal structures of the compounds are stabilized by hydrogen bonds and π⋯π interactions. The antimicrobial activity of the compounds shows that they are effective against some bacteria.
DOI: 10.15372/JSC20150727 |
