Издательство СО РАН

Издательство СО РАН

Адрес Издательства СО РАН: Россия, 630090, а/я 187
Новосибирск, Морской пр., 2

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Яндекс.Метрика

Поиск по журналу

Журнал структурной химии

2010 год, номер 5

NMR Investigation on the Interaction of β-Cyclodextrin and Ampicillin

S.K. Upadhyay1, S.M. Ali2
1 Department of Chemistry, Aligarh Muslim University, Aligarh - 202 002, UP, India, skupadhyay@msn.com
2 Department of Chemistry, Aligarh Muslim University, Aligarh - 202 002, UP, India
Ключевые слова: NMR spectroscopy, COSY, ROESY, inclusion complex
Страницы: 1003-1006

Аннотация

The penetration of ampicillin molecule into the β-cyclodextrin cavity in aqueous solution is studied by 1H NMR, 2D COSY and ROESY spectroscopy. Obtained data suggest that the phenyl moiety of ampicillin is included inside the hydrophobic cavity of β-cyclodextrin molecule in the solution, and the mode and depth of this inclusion is confirmed on the basis of 2D ROESY spectral data.