PLACE OF LOW-MOLECULAR-WEIGHT HEPARINS IN INTENSIVE THERAPY OF HEPATIC INSUFFICIENCY
Alexey Nikolaevich SHMAKOV1, Kristina Vladimirovna BUDAROVA1, Natalya Lvovna ELIZAREVA1, Vladimir Nikolaevich KOKHNO2
1Novosibirsk State Regional Clinical Hospital, Novosibirsk State Medical University of Minzdrav of Russia
shmakov1948@inbox.ru
2Novosibirsk State Regional Clinical Hospital
kair2007@mail.ru
Keywords: низкомолекулярные гепарины, печеночная недостаточность, интенсивная терапия
Abstract
The practical significance
of heparin low-molecular fractions as inhibitors of inflammation and
antithrombin III consumption reduction were studied. That is most
critical in acute hepatic failure. The study was performed using the
low-molecular-weight heparin (Nadroparin calcium) in low (prophylactic)
doses of 2000 anti-factor Xa units daily per 1 meter squared in the form
of continuous intravenous infusion. The cohort study proved the
nadroparin positive effect on carbohydrate and protein metabolism in
children with acute poisoning by hepatotoxic poisons, The significant
decrease in the quantitative assessment of disseminated intravascular
coagulation relative to the comparison group has been revealed, and the
decrease in 28-day mortality from 42 to 13 % has been found in children
receiving nadroparin. Conclusions are drawn on the feasibility of
introducing low molecular weight heparins into the intensive care
regimen of liver failure.
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