QUALITY OF LIFE IN PATIENTS WITH MYELOPROLIFERATIVE NEOPLASMS (REVIEW)
Igor Leonidovich DAVYDKIN, Natalya Sergeevna POPELNYUK, Kseniya Viktorovna NAUMOVA, Elizaveta Vladimirovna MORDVINOVA, Tatyana Yurevna STEPANOVA, Svetlana Petrovna KRIVOVA, Anastasiya Aleksandrovna ROGOZINA, Tatyana Pavlovna KUZMINA
Samara State Medical University of Minzdrav of Russia
Keywords: миелопролиферативное заболевание, хронический миелолейкоз, истинная полицитемия, качество жизни, myeloproliferative disease, chronic myeloid leukemia, polycythemia vera, quality of life
Abstract
The target drugs use showed high efficiency and raised the patients’ life expectancy approaching it to average on population and became the new era in hematooncology. Given the currant tendency, the investigation of problems of patients’ quality of life and the affecting factors is actual. We have analyzed the modern foreign and domestic literature data concerning the quality of life of patients with myeloproliferative diseases and their variation principal causes and parameters reflecting the phenomenon. Also, we state the basic information on diseases where the myeloid lineage hyperplasia is the root cause. The pathophysiological and clinical features of the blood system pathologies are specified. The high-priority factors influencing quality of life of patients with myeloproliferative diseases are highlighted. The basic mechanisms of cardiovascular and thrombotic events development, playing a key role in the patients quality of life forming are in more detail described on the example of chronic myeloid leukemia and polycythemia vera. Moreover, the expediency of search of new diagnostic approaches to the assessment of myeloproliferative diseases course and the patients’ quality of life on a background of modern therapy have been shown.
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