PROTEIN MARKERS OF CARDIONECROSIS IN THE DYNAMICS OF ACUTE CORONARY SYNDROME
Mikhail Ivanovich VOEVODA1,2,3, Natalya Nikolaevna YAROKHNO2, Margarita Vitalyevna KRUCHININA2,4, Yuliya Igorevna RAGINO2, Vladimir Nikolaevich KRUCHININ5, Konstantin Yuryevich NIKOLAEV2,3
1Institute of Cytology and Genetics of SB RAS
2Research Institute of Internal and Preventive Medicine - Branch of the Institute of Cytology and Genetics of SB RAS
3Novosibirsk State University
4Novosibirsk State Medical University of Minzdrav of Russia
5Rzhanov Institute of Semiconductor Physics of SB RAS
Keywords: белковые маркеры, кардионекроз, острый коронарный синдром, динамика, возраст, protein markers, cardiac necrosis, acute coronary syndrome, dynamics, age
Abstract
The aim of this study was to compare and analyze the effectiveness of protein markers of myocardial necrosis - heart-type fatty acid-binding protein (H-FABP) and the MB fraction of creatine phosphokinase (CPK-MB) in the dynamics of acute coronary syndrome. Material and methods. A total of 49 patients (57.1 ± 11,0 years) were examined, including 36 male patients (73.5 %) who were admitted to the City Clinical Hospital No. 34 of Novosibirsk with suspected acute coronary syndrome. The content of H-FABP in whole venous blood was evaluated for all patients upon admission to the hospital with the means of the immunochromatographic rapid test «CardioPBFA» (NPO «Biotest», Novosibirsk) with a sensitivity of 15 ng/ml. Determination of CPK-MB was carried out repeatedly in the first 48 hours from the beginning of the clinical manifestations of the disease, using immunochemiluminometric assay. Results and discussion. It was revealed that in patients with myocardial infarction (MI), CPK-MB content after 6-24 hours and also after 24-48 hours from the onset of pain was significantly higher than in patients without MI. H-FABP content 15 ng/ml and more, determined in the majority of patients in the first 6 hours from the onset of pain, was recorded much more often in MI presence than in MI absence. Using partial correlation analysis, it was determined that age influenced the association of MI with CPK-MB 6-24 hours after the onset of pain (which is probably due to the increase in the influence of a number of factors modulating the level of protein cardiac markers with age), and the correlation of MI with CPK-MB in 24-48 hours from the onset of pain did not depend on this factor ( r = 0.322; p = 0.46). In the regression model (χ² = 13.6; p = 0.001) it was revealed that H-FABP content 15 ng/ml and more regardless of age ( p = 0.006) is associated with the presence of MI in the patients, which confirms information about the high significance of identifying this H-FABP level in early diagnosis of myocardial infarction.
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