STRUCTURAL AND FUNCTIONAL FEATURES OF THE LIVER WITH MARKERS OF HCV- AND HBV-INFECTION AND OF GASTRIC MUCOSA FOR VARYING DEGREES OF Helicobacter pylori COLONIZATION
David L’vovich NEPOMNYASHCHIKH1, Olga Alexeevna POSTNIKOVA1, Elena Ivanovna MIGUS’KINA2, Ekaterina Eduardovna ABRAMOVA1
1Novosibirsk State Medical University of Minzdrav of Russia
2Novosibirsk Regional Clinical Hospital
Keywords: хронические HCV- и HBV-инфекции, гепатопатия, гастропатия, Helicobacter pylori
Abstract
The aim of the investigation was to study the structural features of the liver cell populations and gastric mucosa at varying intensity of Helicobacter pylori colonization in patients with HCV and HBV infection markers. Material and methods. The clinical and morphological study of 95 patients with markers of HCV and HBV infection and with gastric dysfunction (52 men and 43 women aged 16 to 66 years) and 56 patients with chronic gastritis has been carried out. The results have been compared to the degree of H. pylori infection. Results and discussion. It is shown that in all patients with chronic hepatitis the gastric mucosa is involved in the pathological process while the fibrosing form of lesions - gastropathy predominated. The significant correlation between structural changes and the hepatitis activity degree as well as with the presence of H. pylori has not been revealed. Analysis of the stomach structural changes in patients with chronic gastritis, depending on the presence of H. pylori and the infection intensity showed that the catarrhal-fibrotic process predominates in gastric mucosa in case of high degree of H. pylori activity and fibrosing changes predominate in the absence of H. pylori .
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