BIOCHEMICAL MARKERS OF ENDOTHELIAL DYSFUNCTION AND HEMOSTASIS IN ATHEROSCLEROSIS AND THE GENES RESPONSIBLE FOR THEIR REGULATION
E.V. Stryukova, Yu.I. Ragino, V.N. Maksimov
Institute of Internal and Preventive Medicine, 630089, Novosibirsk, Boris Bogatkov str., 175/1
Keywords: атеросклероз, эндотелиальная дисфункция, гемостаз, полиморфизмы генов, асимметричный диметиларгинин, эндотелин-1, адгезивные молекулы ICAM, VCAM, аполипопротеины, антитромбин III, рецептор урокиназного активатора плазминогена, ингибитор пути тканевого фактора, фактор свертывания крови VII, фактор свертывания XII, протромбин, atherosclerosis, endothelial dysfunction, hemostasis, gene polymorphisms, asymmetric dimethylarginine, endothelin-1, adhesion molecules ICAM, apolipoproteins, antithrombin III, receptor of urokinase plasminogen activator, tissue factor pathway inhibitor, blood coagulation factor VII, XII, prothrombin
Abstract
The review systematized modern concepts of markers of endothelial dysfunction and disorders of hemostasis (asymmetric dimethylarginine, endothelin 1, adhesive ICAM and VCAM molecules, apolipoproteins, antithrombin III, receptor of urokinase plasminogen activator, tissue factor pathway inhibitor, blood coagulation factors VII, XII, prothrombin) associated with atherogenesis, and genes responsible for their regulation.
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