RAMAN-SPECTROSCOPY OF HEMOGLOBINE IN DIAGNOSTICS OF RESISTANT ARTERIAL HYPERTENSION
M.V. Kruchinina1, Ya.Sh. Schwartz1, A.A. Gromov1, V.N. Kruchinin2, V.A. Volodin2,3, S.V. Rykhlitsky2
1Therapy and Preventive Medicine Institute, Novosibirsk, Russia
2Institute of Semiconductor Physics, Novosibirsk, Russia
3NGU, Novosibirsk, Russia
Keywords: Raman-спектроскопия, гемоглобин, резистентная артериальная гипертензия, диагностики, Raman-spectroscopy, hemoglobin, resistant hypertension, diagnostics
Abstract
With the means of Raman-spectroscopy the changes in hemoglobin complexes in hypertensive patients (42 men), including resistant hypertension (19 people) have been studied. There is a significant decrease in the level of complexes Hb-NO (II) in patients with GRA, compared with those in patients with controlled hypertension and healthy. Discriminatory values determined Raman peak levels of hemoglobin complexes in hypertensive patients (including resistant) and in the comparison group have been observed. Set the most significant peaks of Raman-spectra of hemoglobin levels allowed the controlled and differentiated resistant hypertension - 1325, 1350, 1550, 1580, 1660, 1668 cm-1 (AUC - 0,680-0,805). The possibility of application of these parameters for diagnostic purposes was discussed.
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